The ADAMS A1c, HA-8180T is a fully automated Glycohemoglobin analyzer based on HPLC (High Performance Liquid Chromatography) and is highly effective for ß-thalassemia testing. Measurement speed: 3.5 minutes/test Measurement Item as below HbA2 HbF HbA1c (Stable HbA1c, S-A1c), HbS, HbC, HbE and HbD can be detected. Column design with no more pre-filter change. Color LCD with reagent level, graphs on screen. Samples Whole blood or hemolysis sample Measurement items HbA1c（Stable HbA1c, S-A1c）, HbA2 and HbF (HbS, HbC, HbE and HbD can be detected.） Reagents *1 ELUENT 80A, ELUENT 80B, ELUENT 80CT and HEMOLYSIS WASHING SOLUTION 80H Column *2 COLUMN UNIT 80T Measurement principle Reversed-phase cation exchange chromatography Detection method Dual-wavelength colorimetry (wavelengths measured: 420nm/500nm） Resolution 0.1% Ratio, 1 mmol/mol Measurement range *3 HbA1c : 3-20%, 9-195 mmol/mol HbA2 : 2-10% HbF : 0-100% Guaranteed measurement range *4 HbA1c : 4.2-12.9%, 22-117 mmol/mol HbA2 : 2.4-6.3% HbF : 0.1-14.3% Processing speed 210 seconds per sample Sample consumption Approx.14μL（whole blood） Sample container Blood collection tube （12.3 to 15mm diameter) × ( 75 to 100mm length） Sample cup（500μL） Sampling method Cap-Piercing Rack type ARKRAY racks Number of measurement samples One-way transportation (factory set) : Maximum 50 samples Loop transportation : Maximum 100 samples Column temperature Approx. 39℃ Display Color graphic LCD with backlight Memory capacity 500 test results ( including calibration results ) Built-in Printer Termal printer, 58mm thermal paper External output Serial 1 port (Can be optionally used as an Ethernet port.) Measurement conditions Temperature : 15-30℃ Humidity : 20-80% relative humidity (non-condensing ) Required sample volume Blood collection tube : Minimum 10mm away from the bottom Sample cup : 400μL or more Warm-up time Maximum 30 min. Dimensions 530（W）×530（D）×530（H）mm (Not including the hemolysis washing solution bottle) Weight Analyzer: Approx. 39kg, Sampler: Approx. 4kg Power supply AC100V-240V ±10% 50/60Hz Power consumption Max. 300 VA *1, *2 Reagents and column are sold separately from HA-8180T analyzer. *3 Error-free measurement ranges. *4 Guaranteed ranges for obtaining results equivalent to those from HA-8160 TP mode measurement. ※Design and specications may be changed without prior notice

Product Features: Better precision, CV < 2.5 % Patented CLE technology enables complete elimination of labile glycohemoglobin ensuring accurate HbA1c results. HbA1c test results in 3.5 minutes with HbA2/HbF flagging. Separation of hemoglobin fractions Complete removal of labile fraction up to 10% No interference of HbF up to 10% No interference of lipemia or icterus, can run on non-fasting patient samples HbA1c reportability presence of HbS, HbC, HbD and HbE Compact bench top model User friendly touch screen operation Sampling from multiple sized primary tubes, including microcapillary collection tubes On board QC functions with Levey-Jennings and statistical calculations Unlimited storage of calibration, QC data and chromatograms No sample preparation required Simple reagent and column replacement Automated maintenance RFID reagent identification and tracking Automatic barcode identification of samples NGSP certified Calibrators and Controls IFCC traceable Complete kit with buffers, calibrator and column Product Application: Hba1c Testing Sampler Handler: 10 Position Rack Loader, positive identification by internal barcode reader Sample Type: Whole blood on EDTA K3 or K2 anticoagulant Haemolysate from EDTA whole blood samples Time for Analysis: Throughput approximately 3.5 minutes between samples Interferences: Complete removal (not separation) of labile up to 10% Sampling System: Sample Aspiration Probe coupled with a high precision, Sample Aspiration Volume: 14.5 µl in whole blood, 670 µl in lysate mode. Pump: 2 high pressure syringe pumps Detector Type: UV-Vis Reagent Traceability: RFID Printer: Built- in thermal printer with possibility to connect to external printer

For smaller Laboratories Smaller, but with full functionality Compact size Full functions and performance in a compact size. *Size comparison with HA-8180V Accuracy HPLC technology provides accurate results-inluding detailed chromatogram. it will be shown in both IFCC and NGSP units. Cap-piercing method ADAMS Lite uses a cap-piercing method which enables the placement of capped blood samples. This not only reduces the workload but also helps protect lab technicians from infection. Easy-to-maintain No special tools are required for daily maintenance. Exchanged parts are hand-tightened, minimizing the workload of users. Specifications Measurement objects Whole blood or hemolysis sample Measured items Fast Mode: HbA1c (Stable HbA1c, S-A1c) and HbF Variant Mode: HbA1c (Stable HbA1c, S-A1c) and HbF (HbS and HbC separation and HbE and HbD detection can be performed). Measurement principle Reversed-phase cation exchange chromatography Measurement wavelength 420 nm/500 nm (Dual-wavelength colorimetry) Resolution 0.1% Ratio, 1 mmol/mol Measurement range HbA1c: 3 - 20%, 9 - 195 mmol/mol HbF: 0 - 100% Processing speed Variant mode: 160 seconds/test Fast mode: 100 seconds/test Sample consumption Whole blood sample: Approximately 4µL Anemia sample: Approximately 8 µL Hemolysis sample: Approximately 350 µL Sample container Sample tube: (12.3 or 15 mm in outer diameter) × (75 to 100 mm in height) Sample cup: 500 µL Sample supply Piercing sampling Compatible rack type ARKRAY racks (for 5 samples) Operating environment Temperature: 10 - 30°C; Humidity: 20 - 80% RH (No condensation) Display 20 digits × 2 lines LCD Printer For use with 58-mm width thermal printer paper Number of measurement samples Maximum 10 samples Power requirements AC 100 - 240 V±10%, 50/60 Hz Dimensions 330 (W) × 515 (D) × 485 (H) mm (Not including protrusions, eluent packs and hemolysis washing solution bottle)

The ADAMS A1c, HA-8180 is a fully automated Glycohemoglobin (HbA1c) analyzer based on HPLC (High Performance Liquid Chromatography). HbA1c is a good parameter for long-term blood glucose monitoring in patients suffering from diabetes mellitus. Measurement Speed: 48 sec/test for Fast Mode and 90 sec/test for Variant mode. Measurement items are as follows. HA-8180V, Fast Mode HbA1c (Stable HbA1c, S-A1c) and HbF HA-8180V, Variant Mode　 HbA1c (Stable HbA1c, S-A1c) and HbF HbS and HbC separation and HbE and HbD detection can be performed. ・Column design with no more pre-filter change ・Economical - improved aluminium reagents for more efficient reagent supply ・Color LCD with reagent level, graphs on screen Specifications Configuration Main body, sampler (with sample tube spinning unit) and accessories Measurement objects Whole blood or hemolysis sample Column COLUMN UNIT 80 Reagents ELUENT 80A, ELUENT 80B, ELUENT 80CV and HEMOLYSIS WASHING SOLUTION 80H Measurement items Fast Mode HbA1c (Stable HbA1c, S-A1c) and HbF Variant Mode HbA1c (Stable HbA1c, S-A1c) and HbF (HbS and HbC separation and HbE and HbD detection can be performed) Measurement ranges *1 HbA1C: 3 - 20%, 9 - 195 mmol/mol HbF: 0 - 100% Guaranteed measurement ranges *2 HbA1C: 4 - 16%, 20 - 151 mmol/mol HbF: 0.3 - 5% Measurement principle Reversed-phase cation exchange chromatography Measurement wavelength 420 nm / 500 nm (Dual-wavelength colorimetry) Sample supply Sampler Resolution 0.1 % Ratio, 1 mmol / mol Processing speed Variant mode : 90 seconds / test Fast mode : 48 seconds / test Sample consumption Approximately 14 μL (Whole blood) Required sample volume Sample tube : Minimum 10 mm away from the bottom Sample cup : 400 μL or more Sample container Sample tube : (12.3/15 mm diameter) × (75 to 100 mm length) Sample cup: 500 μL Compatible rack type ARKRAY racks Number of measurement samples One-way transportation (factory-set) : Maximum 50 samples Loop transportation : Maximum 100 samples Column temperature Approximately 40°C Warm-up time Maximum 30 minutes Display Large color LCD with backlight Printer For use with 58-mm width thermal printer paper Memory capacity 900 measurement results (including calibration results) External output Serial 1 port (Can be optionally used as an Ethernet port.) Communication system RS-232C compliant (Switchable between one-way and two-way communications.) Transmission speed RS-232C : Selectable from 300, 600, 1200, 2400, 4800, 9600 and 19200 bps Ethernet: 10BASE-T Dimensions 530 (W) × 530 (D) × 530 (H) mm (Not including the hemolysis washing solution bottle) Weight Main body: Approximately 39 kg, Sampler: Approximately 4 kg Power requirements 100 - 240 V AC ± 10 %, 50 / 60 Hz Power input Maximum 300 VA *1 Error-free measurement ranges *2 Guaranteed ranges for obtaining results equivalent to those from HA-8160 VP mode measurement